A fanatic, a person with an obsession.
An insane person, especially one who suffers from a mania.
The participant who opens an academic debate by putting forward objections to a theological or philosophical thesis.
One who opposes another; one who works or takes a position against someone or something; one who attempts to stop the progress of someone or something.
One who opposes another in words (in a dispute, argument or controversy).
One who is opposed or objects (to a policy, course of action or set of ideas).
One who opposes another physically (in a fight, sport, game, or competition).