To defeat, refute, discredit, or consume utterly (as a theory, belief or opponent).
To destroy (of buildings, especially in a planned and intentional fashion).
To influence or control someone in order to achieve a specific purpose, especially one that is unknown to the one being manipulated and beneficial to the manipulator; to use
To move, arrange or operate something using the hands
To handle and move a body part, either as an examination or for a therapeutic purpose
To influence, manage, direct, control or tamper with something