The act or state of deliberately not paying attention or caring about; misregard.
To ignore; pay no attention to.
To influence or control someone in order to achieve a specific purpose, especially one that is unknown to the one being manipulated and beneficial to the manipulator; to use
To move, arrange or operate something using the hands
To handle and move a body part, either as an examination or for a therapeutic purpose
To influence, manage, direct, control or tamper with something