To control (a machine, vehicle, situation, etc.) by means of physical strength.
To mishandle; to handle roughly; to mangle.
To move something heavy by force of men, without aid of levers, pulleys, machine, or tackles.
To assault or beat up a person.
To influence, manage, direct, control or tamper with something
To influence or control someone in order to achieve a specific purpose, especially one that is unknown to the one being manipulated and beneficial to the manipulator; to use
To move, arrange or operate something using the hands
To handle and move a body part, either as an examination or for a therapeutic purpose