To influence, manage, direct, control or tamper with something
To influence or control someone in order to achieve a specific purpose, especially one that is unknown to the one being manipulated and beneficial to the manipulator; to use
To move, arrange or operate something using the hands
To handle and move a body part, either as an examination or for a therapeutic purpose
To hand over (something to someone), place into the care or control of another.
To quit (a job or position).
To submit passively; to give up as hopeless or inevitable.
To give up; to relinquish ownership of.