To dull the senses of (a person, place etc.).
To make into a narcotic.
To use a narcotic in order to make (someone) drowsy or insensible; to anesthetize, to drug.
To cause (the mind, faculties, etc.) to be less acute.
To cause (a feeling) to be less intense.
To cause to become numb (physically or emotionally).
To become numb (especially physically).
Physically unable to feel, not having the power of sensation.
Emotionally unable to feel or respond in a normal way.