A person in desperate circumstances or who is at the point of desperation, such as a down-and-outer, addict, etc.
Extremely bad; outrageous, shocking; intolerable.
In dire need (of something); having a dire need or desire.
Intense; extremely intense.
Being filled with, or in a state of, despair; hopeless.
Beyond hope, leaving little reason for hope; causing despair; extremely perilous.
Involving or employing extreme measures, without regard to danger or safety; reckless due to hopelessness.
Able to be neglected, ignored or excluded from consideration; too small or unimportant to be of concern.