To be insensitive, insolent, or rude to (somebody); to affront or demean (someone).
Something causing disease or injury to the body or bodily processes; the injury so caused.
Something that causes offence (for example, by being of an unacceptable quality).
Action or form of speech deliberately intended to be rude; (countable) a particular act or statement having this effect.
To be indebted to someone.
To constrain someone by force or by social, moral or legal means.
To do (someone) a service or favour (hence, originally, creating an obligation).