Over the edge; especially, off or outside of a boat.
Excessively; too much.
Outside of a boat; in the water.
To throw over the edge of a boat into the water.
Of a pathogen: replicating within its host cell, then immediately causing it to undergo lysis.
Extremely hostile or malicious; intensely acrimonious.
Of a disease or disease-causing agent: malignant, able to cause damage to the host.
Of animals, plants, or substances: extremely venomous or poisonous.