To render unable; to take away an ability of, as by crippling.
To impair the physical or mental abilities of; to cause a serious, permanent injury.
To deactivate, to make inoperational (especially of a function of an electronic or mechanical device).
To push a pawn too far, so that it becomes vulnerable to the opponent's attacks.
To expand or extend to an excessive degree, especially to do so beyond a safe limit.
To apply (a term) to too many referents, by overextension.