An unpleasant or difficult experience or incident.
A woman, women, or bottom (i.e. submissive partner, not the top) as a source of sex.
An extremely unpleasant or objectionable person (in US, especially a woman; in UK, Ireland, Australia, New Zealand more usually a man).
(with words funny, good) A person (mostly between male friends); compare bastard.
The female genitalia, especially the vulva.
An objectionable object or item.
A bother or nuisance.
To bother, harass, or annoy persistently.