To move, arrange or operate something using the hands
To influence or control someone in order to achieve a specific purpose, especially one that is unknown to the one being manipulated and beneficial to the manipulator; to use
To handle and move a body part, either as an examination or for a therapeutic purpose
To influence, manage, direct, control or tamper with something
To fiddle with; make small adjustments to, for example to something mechanical in order to improve its performance.
To trick.
To sexually stimulate a person or a person's erogenous zone.
Used other than figuratively or idiomatically: play with.