"whatever happens, happens" (more literally "whatever will be, will be") Ostensibly employed to express a personal philosophy of fatalism and acceptance of the future.
Destroyed, usually in an accident; damaged to the point of unusability.
Having been put in a dreadful or embarrassing situation; can range from being pwned in a game to being utterly defeated in an argument or publicly shamed with a stinging insult.
Very intoxicated from alcohol or recreational drugs.