again vs re-

again

adv
  • Another time; once more. 

  • I ask again, I say again; used in repeating a question or statement. 

  • Over and above a factor of one. 

  • Back (to a former place or state). 

  • Moreover; besides; further. 

  • Here too, here also, in this case as well; used in applying a previously made point to a new instance; sometimes preceded by "here". 

  • Tell me again, say again; used in asking a question to which one may have already received an answer that one cannot remember. 

  • Used metalinguistically, with the repetition being in the discussion, or in the linguistic or pragmatic context of the discussion, rather than in the subject of discussion. 

re-

prefix
  • back, backward 

  • again, anew 

  • a completive or intensification of the base; up, a-, out 

How often have the words again and re- occurred in a corpus of books? (source: Google Ngram Viewer )