To sign again; to provide one's signature again.
To sign a contract renewing or restarting a professional relationship, such as that of a professional athlete with a sports team.
To create a sign out of something.
To show one’s intentions with a sign etc.; to indicate, announce.
To mean; to betoken.
To make a difference; to matter (in negative or interrogative expressions).
To give (something) a meaning or an importance.