To cause to despair.
To be hopeless; to have no hope; to give up all hope or expectation.
That which causes despair.
Loss of hope; utter hopelessness; complete despondency.
That which is despaired of.
To feel sorry about (any thing).
To feel sorry about (a thing that has or has not happened), afterthink: to wish that a thing had not happened, that something else had happened instead.
Emotional pain on account of something done or experienced in the past, with a wish that it had been different; a looking back with dissatisfaction or with longing.
The amount of avoidable loss that results from choosing the wrong action.