To release (someone) from or of a difficulty, unwanted task, responsibility etc.
To ease (someone, a part of the body etc.) or give relief from physical pain or discomfort.
To ease (a person, person's thoughts etc.) from mental distress; to stop (someone) feeling anxious or worried, to alleviate the distress of.
To free (someone) from debt or legal obligations; to give legal relief to.
To alleviate (pain, distress, mental discomfort etc.).
To urinate or defecate.
To ease one's own desire to orgasm, often through masturbation to orgasm.
To bring military help to (a besieged town); to lift the siege on.
To free (someone) from their post, task etc. by taking their place.
To provide comfort or assistance to (someone in need, especially in poverty).
To free (something) from a hindrance or annoyance.
Released from an obligation, problem, etc. (usually followed by of).