Reasonably large in number or amount.
Having a low probability of occurring by chance (for example, having high correlation and thus likely to be related).
Having a covert or hidden meaning.
Having a noticeable or major effect.
Signifying something; carrying meaning.
That which has significance; a sign; a token; a symbol.
Large in size, quantity, or value; ample; significant.
Most important; essential.
Not imaginary; real; actual; true; veritable.
Having a substance; actually existing.
Corporeal; material; firm.
Possessed of goods or an estate; moderately wealthy.
Satisfying; having sufficient substance to be nourishing or filling.
Having good substance; strong; stout; solid; firm.
Anything having substance; an essential part.