Violent turmoil.
An uncontrolled fit, as of laughter; a paroxysm.
An intense, paroxysmal, involuntary muscular contraction.
A disaster, especially one which is large in scale and readily seen by public observers.
The aftermath of a train crash.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.
To ruin utterly and catastrophically, to cause to end in disaster.