An unexpected natural or man-made catastrophe of substantial extent causing significant physical damage or destruction, loss of life or sometimes permanent change to the natural environment.
An unforeseen event causing great loss, upset or unpleasantness of whatever kind.
A disaster, especially one which is large in scale and readily seen by public observers.
The aftermath of a train crash.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.
To ruin utterly and catastrophically, to cause to end in disaster.