Cause of misery; calamity; misfortune.
A bodily ache or pain.
Great unhappiness; extreme pain of body or mind; wretchedness; distress; woe.
poverty.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.
The aftermath of a train crash.
A disaster, especially one which is large in scale and readily seen by public observers.
To ruin utterly and catastrophically, to cause to end in disaster.