A disastrous event, especially one involving great loss of life or injury.
A drama or similar work, in which the main character is brought to ruin or otherwise suffers the extreme consequences of some tragic flaw or weakness of character.
The genre of such works, and the art of producing them.
A disaster, especially one which is large in scale and readily seen by public observers.
The aftermath of a train crash.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.
To ruin utterly and catastrophically, to cause to end in disaster.