A disaster, especially one which is large in scale and readily seen by public observers.
The aftermath of a train crash.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.
To ruin utterly and catastrophically, to cause to end in disaster.
An event that causes great distress.
An emotional wound leading to psychological injury.
Any serious injury to the body, often resulting from violence or an accident.