A disaster, especially one which is large in scale and readily seen by public observers.
The aftermath of a train crash.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.
To ruin utterly and catastrophically, to cause to end in disaster.
Calamity, trouble.
Great sadness or distress; a misfortune causing such sadness.
A curse; a malediction.