A grave nuisance, whatever greatly irritates.
A group of common grackles.
A widespread affliction, calamity or destructive influx, especially when seen as divine retribution.
The bubonic plague, the pestilent disease caused by the virulent bacterium Yersinia pestis.
An epidemic or pandemic caused by any pestilence, but specifically by the above disease.
To harass, pester or annoy someone persistently or incessantly.
To afflict with a disease or other calamity.
A distressing or dangerous situation.
A difficulty, problem, condition, or action contributing to such a situation.
A fault or interruption in a stratum.
A malfunction.
A violent occurrence or event.
Efforts taken or expended, typically beyond the normal required.
Liability to punishment; conflict with authority.
Wife. Clipping of trouble and strife.
In weaker sense: to bother or inconvenience.
To mentally distress; to cause (someone) to be anxious or perplexed.
To worry; to be anxious.
To take pains to do something.