microorganism vs vacuole

microorganism

noun
  • An organism that is too small to be seen by the unaided eye, especially a single-celled organism, such as a bacterium. 

vacuole

noun
  • A large membrane-bound vesicle in a cell's cytoplasm. 

  • A small empty or air-filled space or vacuity. 

How often have the words microorganism and vacuole occurred in a corpus of books? (source: Google Ngram Viewer )