Important or significant.
Mature, conscientious, principled; generous.
Popular.
Large with young; pregnant; swelling; ready to give birth or produce.
Enthusiastic (about).
Fat.
Adult; (of a child) older.
Populous.
Used as an intensifier, especially of negative-valence nouns
Of great size, large.
Operating on a large scale, especially if therefore having undue or sinister influence.
Well-endowed, possessing large breasts in the case of a woman or a large penis in the case of a man.
Old, mature. Used to imply that somebody is too old for something, or acting immaturely.
The participant in ageplay who acts out the older role.
An important or powerful person; a celebrity; a big name.
A initiated member of a sorority who acts as a mentor to a new member (the little).
One or more kinds of barley, especially six-rowed barley.
The big leagues, big time.
In a large amount or to a large extent.
On a large scale, expansively.
You've got to think big to succeed at Amalgamated Plumbing.
In a boasting manner.
Hard.
In a loud manner.
Important; serious; not trivial or petty.
Rigorous; severe; afflictive.
Heavy (“having a lot of weight”).