A humiliating insult or instance of bad treatment, especially when one is expecting friendship or in need of support; a sudden and unexpected setback; a strong rebuff.
Something that causes bitterness or affliction; a cause of mortification or vexation.
An intensely bitter herb (Artemisia absinthium and similar plants in genus Artemisia) used in medicine, in the production of absinthe and vermouth, and as a tonic.