To reduce to nothing, to destroy, to eradicate.
To render null and void; to abrogate.
To react with antimatter, producing gamma radiation and (for higher-mass reactants, especially composite particles such as protons) lighter particles (such as pions, muons, and neutrinos).
To outdo or defeat, especially in battle.
Most unfavorable.
Used with the definite article and an implied noun: something that is worst.
Most inferior; doing the least good.
Most harmful or severe.
Something or someone that is the worst.